Endocrine Abstracts

Thyroid hormone is a major determinant of tissue functions in vivo. Within the tissues, cells are not passive players in the process of hormonal signaling since they can actively customize hormonal action. Triiodothyronine (T3), the active form of thyroid hormone is produced predominantly outside the thyroid parenchyma secondary to peripheral tissue deiodination of thyroxine (T4), with <20% being secreted directly from the thyroid. Upon entering the cells via specific tran...

Thyroid hormone is a major determinant of tissue functions in vivo. Within the tissues, cells are not passive players in the process of hormonal signaling since they can actively customize hormonal action. Triiodothyronine (T3), the active form of thyroid hormone is produced predominantly outside the thyroid parenchyma secondary to peripheral tissue deiodination of thyroxine (T4), with <20% being secreted directly from the thyroid. Upon entering the cells via specific tran...

Thyroid hormones (TH) are endocrine molecules necessary for multiple biological processes that are crucial to tumor growth and differentiation. Several reports pointed out a pivotal role of thyroid status in the tumoral behavior.TH action is regulated by the action of the deiodinases. Type 2 deiodinase (D2) activates thyroxine (T4) by converting it to T3, whereas D3, by inactivating T3, terminates thyroid hormone action.Thus, the deiodinase family of sel...

Fibro-adipogenic progenitors (FAPs), a muscle-resident stem cell population, have recently emerged as important actors of muscle regeneration by interacting with myogenic progenitors (MPs) to promote the formation of new muscle fibers. However, in pathological condition, as muscle dystrophies, this coordinated response is lost and then an accumulation of FAPs is observed. In particular, in a mouse model of Duchenne muscle dystrophy (mdx), the accumulation of a specific subpopu...

Purpose: Treatment with tyrosine kinase inhibitors (TKI) has been associated with alterations in circulating thyroid hormone levels, possibly related to perturbations in peripheral thyroid hormone metabolism. In this study, we evaluated the effect of the multi-kinase inhibitor vandetanib on the expression of the three deiodinase selenoenzymes.Materials and Methods: Cell models that endogenously express either D1 (HepG2 and HEK-293), D2 (HeLa and KMH-2) o...